Located on a sprawling twenty eight-acre campus at 100 South Carlen street near downtown Mobile, Murphy High School is a proud tradition of excellence. Fourteen buildings accommodate approximately 2200 students and 110 faculty and staff members. In 1982, Murphy High School was placed on the United States Department of the Interior National Register of Historic Places.
In April, 1976 Murphy celebrated its golden anniversary as the oldest school in Alabama. Originally named Mobile High School, the name of the school was changed in 1927 to Murphy High School in honor of Mr. Samuel S. Murphy, who served as superintendent of schools for Mobile County from 1900-1926.
Murphy High School is a charter member of the Southern Association of Colleges and Schools, the official accrediting agency for the Southern states. It has recently been selected for membership on the College Entrance Examination Board and as a Model High School of the Nation.